PhD position available in our group! (Closed)

Modelling of viral respiratory co-infection dynamics (closed)

A PhD position is available in the VirPath team (CIRI, Lyon, France), to study viral co-infections in the respiratory tract.  

This PhD position is part of a Franco-German project funded by ANR-DFG (MORIARTY) whose objective is to combine experimental approaches with novel analytical methods and mathematical modelling to (i) decipher viral replication dynamics of four main respiratory viruses of various severity, (ii) evaluate how co-infection modulate the individual viral dynamics, (iii) anticipate the efficacy of antiviral treatments, and (iv) understand the impact of co-infections on virulence and transmissibility in the population. 

The PhD project will focus on the in vitro and in vivo experimental part of the program, using human rhinovirus (HRV) and Respiratory Syncytial Virus (RSV) as models of seasonal viruses, and on influenza A viruses (IAV) and SARS-CoV-2 as models of pandemic viruses. We will work with reconstituted human airway epithelium and different animal models relying on immunohistochemical imaging and time course infection measurements to assess cell-type specific infectivity, viral replication kinetics, and innate immunity under physiological relevant conditions. 

This Phd position is opened starting in January 2023

This position will take place in the Centre International de Recherche en Infectiologie (CIRI, http://ciri.inserm.fr) in the VirPath team (Prof Bruno Lina/Dr Manuel Rosa-Calatrava). The project will be carried out within the group led by Dr Olivier Terrier, whose research theme is dedicated to the study of respiratory co-infections (https://olivierterrier.fr).

The CIRI is a highly dynamic environment fostering interactions between virologists, bacteriologists, immunologists and clinicians and providing all the necessary platforms and facilities for the project. The VirPath team is very dynamic and  involved in numerous collaborative projects with academia and industry.

Candidates: We are looking for highly motivated and enthusiastic candidates, who likes teamwork, with good communication skills. 

Application: Candidates are invited to contact Olivier Terrier (olivier.terrier@univ-lyon1.fr)  for further details. Please send an application including a cover letter and a curriculum vitae.