Journal Club – Saliva/diagnostic & Innate Immune memory

At our last journal club (8 December 2023), we discussed two very interesting manuscripts: One concerns the determination of a ‘core’ signature specific to a viral infection and its exploitation in a diagnostic approach in the saliva of patients (Yang et al. mBio 2023), the second concerns antiviral innate immune memory in macrophages following infection by SARS-COV-2 (Lercher et al. BioRxiv, 2023). The programme therefore includes plenty of ‘omics’ as well as virus/virus confection!

Yang Q, Meyerson NR, Paige CL, Morrison JH, Clark SK, Fattor WT, Decker CJ, Steiner HR, Lian E, Larremore DB, Perera R, Poeschla EM, Parker R, Dowell RD, Sawyer SL. Human mRNA in saliva can correctly identify individuals harboring acute infection. mBio. 2023 Nov 9:e0171223. doi: 10.1128/mbio.01712-23. Epub ahead of print. PMID: 37943059.

Alexander Lercher, Jin-Gyu Cheong, Chenyang Jiang, Hans-Heinrich Hoffmann, Alison W. Ashbrook, Yue S. Yin, Corrine Quirk,Emma J. DeGrace, Luis Chiriboga, Brad R.Rosenberg, Steven Z. Josefowicz, Charles M. Rice
Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection. bioRxiv 2023.11.24.568354; doi: https://doi.org/10.1101/2023.11.24.568354